She was born as Florence Agnes Hughes in Radford Semele, Warwickshire, England on 8 March 1876. She was later baptised on 14 May that same year in Whitnash, Warwickshire.
She was the daughter of George Hughes (b. 1844), a shepherd, and Sarah Ann Hawkins (b. 1839). Her father was originally from Mickleton, Gloucestershire whilst her mother hailed from Radstone, Northamptonshire and they had married in Warwickshire in 1865. Florence had eight known siblings: George (b. 1865) Charles Joseph (b. 1867), William Thomas (b. 1869), Mabel Louisa (b. 1872), Walter Richard (b. 1874), Harriet Emily (b. 1877), Jane (b. 1879) and Emma Annie (b. 1882). She also had a half sister, Sarah Elizabeth (b. 1858 in Croughton, Northamptonshire), a daughter of her mother's from a previous and ambiguous relationship.
Florence and her family appear on the 1881 census living in Kingston Cottage in Chesterton, Warwickshire; also living with them was her half-sister Sarah. By the time of the 1891 census the family are living in Heathcote, St Nicholas, Warwickshire. Florence later trained to be a nurse and when she appeared on the 1901 census she was described as an asylum nurse, living and working in the Warwickshire County Asylum for Lunatics in Hatton.
Florence was married in her native Warwickshire in late 1906 to William Angle (b. 1881), a tile maker and fixer originally from Staffordshire. They emigrated only a short while later on 24 November 1906 aboard the Campania and made their home at 339 West 19th Street, Manhattan. They would have no children.
Florence and her husband returned home to England in late 1911 to visit relatives. Her parents and brother Charles lived at 14 Mill Street, Warwick.
Florence survived the sinking, escaping lifeboat 11, but her husband William was lost.
Florence continued to New York where she spent time recuperating due to various respiratory ailments and she garnered work as a housekeeper. Her time in New York proved brief and she returned home to England, arriving in Liverpool on 8 November 1912 aboard the Cedric.
Whether Florence ever returned to New York is not certain. She never remarried and later settled in Leamington Spa, Warwickshire at 33 Arlington Avenue where she lived for many years. She died in a nursing home in Leamington 20 August 1969 aged 93.